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Liquid Handling Specialists

Liquid Handling Method Development & Troubleshooting

Expert support for robotic liquid handling platforms — from method development and liquid class optimisation through to troubleshooting, training, and AI-assisted liquid class development & troubleshooting/optimisation. Available remotely or onsite, with experience across major liquid handling platforms used in life science laboratories.

Method Development
Liquid Class Optimisation
Troubleshooting & Diagnostics
AI-Assisted Method Review
Remote & Onsite Support
Training & Handover

Liquid Handling Problems Are Usually Solvable

Most liquid handling failures come down to a small set of root causes. With the right diagnostic approach, they can be identified and resolved systematically — without expensive engineer call-outs or extended downtime.

High CVs & Poor Reproducibility

Variable results across replicates, plates, or runs — often caused by suboptimal liquid class settings, tip choice, or mixing strategy.

Carryover Between Samples

Cross-contamination between samples or reagents caused by inadequate wash steps, tip reuse, or air gap configuration.

Edge Effects & Plate Variability

Systematic differences between inner and outer wells linked to evaporation, timing, temperature, or dispensing behaviour.

Failed Assay Transfers

Manual-to-automated assay transfers that produce different results — often requiring liquid class reconfiguration and timing review.

Multi-Dispense Drift

Volume accuracy declining over long multi-dispense runs due to reagent properties, dead volume, or dispensing speed settings.

Low Signal or Assay Failure

Reduced assay signal after automation caused by reagent damage, mixing issues, incorrect volumes, or timing changes.

End-to-End Liquid Handling Support

We work across the full lifecycle of a liquid handling method — from initial design and development through to optimisation, documentation, and training.

Liquid Class Optimisation Serial Dilutions Plate-Based Assays Multi-Dispense Setup Air Gap Configuration Mixing Strategy Dead Volume Reduction Carryover Reduction Reagent Optimisation CVs & Accuracy Testing Documentation Operator Training
Method development from scratch — designing liquid handling methods to match your specific assay, reagent, and throughput requirements.
Liquid class optimisation — tuning aspirate/dispense speeds, air gaps, blowout, touch-off, and mixing parameters for specific reagents and volumes.
Assay transfer — moving manual or semi-automated workflows to fully robotic platforms while maintaining performance.
Troubleshooting and root cause analysis — systematic diagnosis of accuracy, precision, carryover, or assay failures using data and protocol review.
Validation and qualification support — supporting IQ/OQ/PQ, method verification, and documentation for regulated environments.
Method documentation and handover — creating clear, maintainable method documentation and operator SOPs.

AI-Assisted Method Review & Troubleshooting

We combine hands-on liquid handling expertise with AI-assisted review tools — helping labs identify issues faster and design more robust methods.

AI-Assisted Method Review

Structured review of your existing liquid handling methods and parameters using AI-assisted analysis to identify likely failure points and optimisation opportunities.

Troubleshooting Assistant

AI-supported diagnostic workflows that help identify root causes of common liquid handling failures — from high CVs and carryover to poor assay transfer results.

Documentation Support

AI-assisted generation of method documentation, SOPs, troubleshooting guides, and training materials — reviewed and verified by our experts before delivery.

Remote or Onsite — Whatever Works for Your Lab

Many liquid handling method issues can be diagnosed and resolved remotely using run data, method files, configuration exports, screenshots, and structured walkthroughs with your team. No travel required, often faster turnaround.

For more complex instrument issues, new method builds, or hands-on training, onsite support is available across Australia.

1

Share your method details

Provide your protocol, run data, liquid classes, error logs, and a description of the problem.

2

Initial assessment

We review the materials and identify likely root causes and the information needed to confirm them.

3

Structured troubleshooting session

Remote call or async review — working through the diagnosis and proposed fixes with your team.

4

Resolution and documentation

Confirmed fix, updated method parameters, and clear documentation of what changed and why.

Need Help With a Liquid Handling Method?

Whether you have an active problem or want to optimise an existing method, we'd love to help. Describe your setup and we'll assess the best way to support you — remotely or onsite.

Based in Australia · Remote support available globally · Typically respond within 24 hours